Qualifying Variant Set Standard (QVSS)
Last update: 20260605
The Qualifying Variant Set Standard (QVSS) defines a minimal, interoperable representation of rule-based criteria used to determine whether records of genetic variation qualify under a declared genomic analysis context.
QVSS is designed to make qualifying variant criteria portable, auditable, reproducible, and reusable across genomic studies, pipelines, registries, and implementation environments.
How to cite this standard
Swiss Genomics Association. (2026). swissgenomicsassociation/sga_qvss: SGA-QVSS-1.0.0 (v1.0.0). Zenodo. https://doi.org/10.5281/zenodo.20553447.
@techreport{sga_qvss_2026,
title = {Qualifying Variant Set Standard {SGA-QVSS-1}.0.0},
author = {{Swiss Genomics Association}},
institution = {Swiss Genomics Association},
year = {2026},
date = {2026-06-05},
number = {SGA-QVSS-1.0},
type = {Normative standard},
journal = {Zenodo},
organization = {Zenodo},
doi = {10.5281/zenodo.20553447},
url = {https://www.swissgenomicsassociation.ch/assets/release/sga_qvss/latest/sga_qvss_1.0.pdf},
howpublished = {\url{https://github.com/swissgenomicsassociation/sga_qvss}},
urldate = {2026-06-05},
version = {sga-QVSS-1.0}
}
Further reading
For further reading on qualifying variants, the following article may be cited, although citation is not required:
Dylan Lawless, Ali Saadat, Mariam Ait Oumelloul, Simon Boutry, Veronika Stadler, Sabine Österle, Jan Armida, David Haerry, D Sean Froese, Luregn J Schlapbach, Jacques Fellay, Application of qualifying variants for genomic analysis, Bioinformatics, Volume 42, Issue 2, February 2026, btaf676, https://doi.org/10.1093/bioinformatics/btaf676.
